LL-37 10mg
LL-37 (Cathelicidin)
CAS: 154947-66-7
LL-37 is the only known human cathelicidin — a 37-residue cationic amphipathic peptide cleaved from the hCAP18 propeptide. Broad-spectrum antimicrobial activity plus immunomodulatory effects including wound healing, angiogenesis stimulation, and anti-biofilm activity. 98.5% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
Disrupts bacterial membranes via amphipathic helix formation. Also binds formyl peptide receptor 2 (FPR2) to modulate macrophage and neutrophil responses. VEGF-A upregulation drives angiogenesis in wound healing models.
Research FAQ
What makes LL-37 unique among antimicrobial peptides?
LL-37 is the sole human cathelicidin. Beyond direct antimicrobial action, it activates FPR2 for immunomodulation, stimulates VEGF-driven angiogenesis, and disrupts bacterial biofilms — a triple functionality not found in other AMPs.
