Melanotan I 10mg
Afamelanotide
CAS: 75921-69-6
Melanotan I (Afamelanotide) is a linear 13-residue alpha-MSH analog with high MC1R selectivity. FDA Breakthrough Designation for erythropoietic protoporphyria (EPP). More selective tanning profile than Melanotan II with minimal CNS MC4R activity. 99.0% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
Potent MC1R agonism in melanocytes drives eumelanin synthesis via cAMP/PKA/MITF pathway, producing a UV-independent photoprotective pigmentation response. High MC1R selectivity compared to the pan-MCR agonism of Melanotan II.
Research FAQ
How does Melanotan I compare to Melanotan II?
Melanotan I is a linear 13-AA analog with near-exclusive MC1R selectivity — tanning with minimal CNS effects. Melanotan II is a cyclic 7-AA analog that activates MC1R through MC5R, producing broader effects including MC4R-mediated appetite and libido modulation.
