PE-22-28 10mg
PE-22-28
CAS: N/A
PE-22-28 is a BDNF loop IV mimetic peptide designed to activate TrkB receptors. Studied for rapid antidepressant-like effects and neuroprotection. Modeled on the neurotrophin interface that engages TrkB without full BDNF size or stability limitations. 99.0% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
Selective TrkB partial agonism mimicking BDNF loop IV interaction. Activates downstream MAPK/ERK and PI3K/Akt neuroprotective pathways while avoiding the tropomyosin kinase-associated pleiotropic effects of full BDNF.
Research FAQ
How does PE-22-28 relate to BDNF?
PE-22-28 is a short peptide mimicking the loop IV region of BDNF that binds TrkB. It produces TrkB-mediated neuroprotection without the pharmacological challenges of the full 27kDa BDNF protein (poor stability, CNS penetration, pan-Trk activity).
