5-Amino-1MQ 50mg
5-Amino-1-methylquinolinium
CAS: 1482516-78-0
5-Amino-1MQ is a small-molecule CD38 inhibitor that blocks the primary NAD-consuming enzyme. By inhibiting CD38, it raises intracellular NAD+ levels, activating sirtuins and improving mitochondrial function. Research shows fat mass reduction and improved metabolic parameters. 99.0% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
Selective CD38 NADase inhibition increases intracellular NAD+, activating SIRT1/SIRT3 deacylases. Downstream effects include PGC-1a upregulation, mitochondrial biogenesis, and reduced adipogenesis via PPAR-gamma inhibition.
Research FAQ
How does 5-Amino-1MQ raise NAD+?
It inhibits CD38, the dominant NAD-consuming enzyme. CD38 activity accounts for up to 60% of NAD+ consumption — blocking it produces a rapid rise in intracellular NAD+, amplifying sirtuin activity downstream.
