FOXO4-DRI 10mg
FOXO4-DRI
CAS: 2173226-03-2
FOXO4-DRI is a D-amino acid retro-inverso peptide designed to disrupt the FOXO4-p53 protein-protein interaction that protects senescent cells from apoptosis. Dasatinib et al. 2017 Nature Medicine demonstrated selective clearance of p16-positive senescent cells in aged mice. 98.7% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
Competes with endogenous FOXO4 for p53 binding in senescent cells, displacing the survival signal that prevents senescent cell apoptosis. Selectively targets cells with high nuclear FOXO4 expression — a hallmark of the SASP-secreting senescent phenotype.
Research FAQ
What is the senolytic mechanism of FOXO4-DRI?
Senescent cells survive via FOXO4-p53 binding in the nucleus. FOXO4-DRI disrupts this interaction, allowing p53 to activate its canonical apoptotic pathway specifically in senescent cells while sparing normal cells.
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Water for Injection, 0.9% Benzyl Alcohol